منابع مشابه
Evolution at a different pace: distinctive phylogenetic patterns of cone snails from two ancient oceanic archipelagos.
Ancient oceanic archipelagos of similar geological age are expected to accrue comparable numbers of endemic lineages with identical life history strategies, especially if the islands exhibit analogous habitats. We tested this hypothesis using marine snails of the genus Conus from the Atlantic archipelagos of Cape Verde and Canary Islands. Together with Azores and Madeira, these archipelagos com...
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Yan et al. describe how a deubiquitinating enzyme complex regulates the mitotic spindle assembly factor NuMA. BRCC36 is a de-ubiquitinating enzyme that preferentially cleaves lysine 63–linked poly-ubiquitin chains. As part of the Rap80 complex, BRCC36 regulates the repair of DNA double-strand breaks, but the enzyme can also assemble into a distinct complex, known as BRISC. Yan et al. found that...
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Overexpression of the ErbB2 (Her2/neu) receptor tyrosine kinase is implicated in the induction and progression of many different types of human cancers. It is particularly frequent in breast cancer, where up to 25% of patients overexpress ErbB2. The ErbB2-positive cancers exhibit extremely malignant and invasive behavior, which is associated with increased disease recurrence and worsened progno...
متن کاملSnails prioritise protein stability at sizzling temperatures.
Dining opportunities are rare for ticks. The notorious pests spend as much as 90% of their lives clambering around in leaf litter and only embark on epic expeditions to the tips of grass and leaves when they need to feed. Wrapping their limbs around slender smooth stalks of grass when they ascend, ticks must also grasp any passing opportunity to latch onto smooth skin or the hairy pelts of anim...
متن کاملHow much at risk are cone snails?
IN THEIR LETTER, “THE THREAT TO CONE snails” (17 Oct., p. 391), E. Chivian et al. estimate that “hundreds of thousands” of cone snails are sacrificed annually for research purposes. We recognize that habitat loss and possible overexploitation of cone snails may indeed threaten the survival of Conus taxa, but we question Chivian et al.’s estimate. This number is huge and shocking in light of the...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1843iti4